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Xanax: Special Warnings and Interactions With Other Medications  


Xanax: When should this anti anxiety medication not be prescribed? 

Front Image - ALPRAZOLAM xanaxXanax should never be prescribed if you're sensitive to or have ever had an allergic reaction to this anti anxiety drug or to other tranquilizers.  You should also avoid Xanax while taking the antifungal drug Sporanox or Nizoral, and you should obviously make sure your doctor is aware if you have any drug reactions while on this medication.

You should not take this anti anxiety medication if you have been diagnosed with narrow-angle glaucoma, which is an eye condition.  You should also be aware that the anxiety and tension related to every day stress usually does not require treatment with drugs such as Xanax.  You should always discuss your symptoms thoroughly with your physician. 

Special warnings about Xanax: 

Xanax has been known to cause you to become drowsy or to have limited alertness; therefore, you should have cautious concern when driving or operating dangerous machinery, or participating in any hazardous activity that requires full mental alertness. 


If you're currently being treated for such anxiety disorders as panic disorder, you may need to take higher doses of Xanax than for a more generalized form of anxiety.  High doses-more than 4 mg a day-of this anti anxiety medication have been known to cause emotional and physical dependence if taken for long durations of time.  It is important that your doctor supervise you carefully when taking this drug.  Also, it is important to remember that withdrawal symptoms can and do occur when Xanax is stop suddenly. 

Possible food and drug interactions when taking this medication: 

You should always be careful when drinking alcohol while taking Xanax.  This medication is known to intensify the effect of alcohol. Also, you should never combine Xanax with Sporanox or Nizoral.  These medications are known to cause a build up of Xanax in the body. 

When taken with certain other medications, Xanax is known to increase, decrease or alter the effects of some medications. You should always check with your doctor when combining Xanax with the following medications: 

  • Amiodarone (Cordarone)

  • Antihistamines such as Benadryl and Tavist

  • Carbamazepine (Tegretol)

  • Certain antibiotics such as Biaxin and Erythromycin

  • Certain antidepressant drugs, such as Elavil, Norpramin, and Tofranil

  • Cimetidine (Tagamet)

  • Cyclosporine (Neoral, Sandimmune)

  • Digoxin (Lanoxin)

  • Diltiazem (Cardizem)

  • Disulfiram (Antabuse)

  • Ergotamine

  • Fluoxetine (Prozac)

  • Fluvoxamine (Luvox)

  • Grapefruit Juice

  • Isoniazide (Rifamate)

  • Major tranquilizers such as Mellaril and Thorazine

  • Nefazadone (Serzone)

  • Nicardapine (Cardene)

  • Nifedipine (Adalat, Procardia)

  • Oral contraceptives

  • Other central nervous system depressants such as Valium and Demerol

  • Paroxetine (Paxil)

  • Propoxyphene (Darvon)

  • Sertraline (Zoloft)

Information adapted from The PDR Pocket Guide to Prescription Drugs - Sixth Edition

xanax ALPRAZOLAMAdditional Pictures of Xanax - Various dosages

Additional information By Paul Susic Ph.D  Licensed Psychologist 

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