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Zoloft: Special Precautions and Interactions

Special precautions about the use of Zoloft:

Front Image -zoloft ( SERTRALINE HYDROCHLORIDE)Special precautions should be taken if you have liver disorder or may be subject to seizures.  You should always take Zoloft under the close supervision of a physician, and especially when you have these types of disorders. 

Zoloft has not usually been found to effect the operation of automobiles or machinery.  However, as with all medications, you should find out how the drug effects you before you attempt these operations.  Also, if you're sensitive to latex, you may want to use precaution when you handle the dropper provided with the oral concentrate. 

Possible food and drug interactions with Zoloft: 

It is recommended that you not drink alcohol when taking Zoloft.  Also the use of over-the-counter remedies should be used with caution.  Although none of these remedies have been found to cause a negative interaction with Zoloft, interactions always remain a possibility.


 If Zoloft is taken with other medications, the effects may be increased, decreased or altered. It is especially important for you to check with your physician when combining Zoloft with any of the following:

  • Cimetidine(Tagamet)

  • Diazepam (Valium)

  • Digitoxin (Crystodigin)

  • Flecaimide (Tambocor)

  • Lithium (Eskalith, Lithobid)

  • MAO inhibitor drugs such as the antidepressants Nardil and Parnate

  • Other serotonin-boosting drugs such as Paxil and Prozac

  • Other antidepressants such as Elavil and Serzone

  • Over-the-counter drugs such as cold remedies

  • Propafenone (Rythmol)

  • Sumatriptan (Imitrex)

  • Tolbutamide (Orinase)

  • Warfarin (Coumadin) 

If you are using the oral concentrate form of Zoloft, do not take disulfiram (Antabuse).

Special information if you are pregnant or breast-feeding 

The effects of Zoloft during pregnancy have not been adequately tested.  If you are currently pregnant or plan on becoming pregnant in the near future consult your physician immediately.  Zoloft should only be taken during pregnancy when you are very depressed and the risks outweigh the benefits.  It's not currently known whether Zoloft appears in breast milk and caution is advised when using Zoloft during breast-feeding. 

Information from the The PDR Pocket Guide to Prescription Drugs - Sixth Edition

By Paul Susic Ph.D. Licensed Psychologist

Front Image - zoloft (SERTRALINE HYDROCHLORIDE)See additional pictures of Zoloft dosages

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